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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Neuronal activation by mucosal biopsy supernatants from irritable bowel syndrome patients is linked to visceral sensitivity
|
|---|---|
| Published in |
Experimental Physiology, July 2014
|
| DOI | 10.1113/expphysiol.2014.080036 |
| Pubmed ID | |
| Authors |
Sabine Buhner, Breg Braak, Qin Li, Eva Maria Kugler, Tamira Klooker, Mira Wouters, Jemma Donovan, Sheila Vignali, Gemma Mazzuoli-Weber, David Grundy, Guy Boeckxstaens, Michael Schemann |
| Abstract |
Based on the discomfort/pain threshold during rectal distension, Irritable Bowel Syndrome (IBS) patients may be subtyped as normo- or hypersensitive. We previously showed that mucosal biopsy supernatants from IBS patients activated enteric and visceral afferent neurons. We tested the hypothesis that visceral sensitivity is linked to the degree of neuronal activation. Normo- and hypersensitive IBS patients were distinguished by their discomfort/pain threshold to rectal balloon distension with a barostat. Using potentiometric and Ca(2+) dye imaging, we recorded the response of guinea pig enteric submucous and mouse dorsal root ganglion (DRG) neurons, respectively, to mucosal biopsy supernatants from normosensitive (n = 12 tested in enteric neurons, n = 9 tested in DRG) and hypersensitive IBS (n = 9, tested in both types of neurons) patients. In addition, we analyzed the association between neuronal activation and individual discomfort/pain pressure thresholds. IBS supernatants evoked Ca(2+) transients in DRG neurons and spike discharge in submucous neurons. Submucous and DRG neurons showed significantly stronger responses to supernatants from hypersensitive IBS patients as reflected by higher spike frequency or stronger [Ca(2+)]i transients in a larger proportion of neurons. The neuroindex as a product of spike frequency or [Ca(2+)]i transients and proportion of responding neurons significantly correlated with the individual discomfort/pain thresholds of the IBS patients. Supernatants from hypersensitive IBS patients caused stronger activation of enteric and DRG neurons. The level of activation correlated with the individual discomfort/pain threshold pressure values. These findings support our hypothesis that visceral sensitivity is linked to activation of peripheral neurons by biopsy supernatants. This article is protected by copyright. All rights reserved. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 67% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 42 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 19% |
| Student > Master | 7 | 17% |
| Student > Doctoral Student | 5 | 12% |
| Researcher | 5 | 12% |
| Student > Bachelor | 5 | 12% |
| Other | 3 | 7% |
| Unknown | 9 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 26% |
| Agricultural and Biological Sciences | 8 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Physics and Astronomy | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 4 | 10% |
| Unknown | 12 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 June 2014.
All research outputs
#15,576,527
of 25,457,297 outputs
Outputs from Experimental Physiology
#1,767
of 2,530 outputs
Outputs of similar age
#123,410
of 240,219 outputs
Outputs of similar age from Experimental Physiology
#7
of 15 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,530 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.5. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 240,219 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.