Title |
Decreasing adrenergic or sympathetic hyperactivity after severe traumatic brain injury using propranolol and clonidine (DASH After TBI Study): study protocol for a randomized controlled trial
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Published in |
Trials, September 2012
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DOI | 10.1186/1745-6215-13-177 |
Pubmed ID | |
Authors |
Mayur B Patel, John W McKenna, JoAnn M Alvarez, Ayaka Sugiura, Judith M Jenkins, Oscar D Guillamondegui, Pratik P Pandharipande |
Abstract |
Severe TBI, defined as a Glasgow Coma Scale ≤ 8, increases intracranial pressure and activates the sympathetic nervous system. Sympathetic hyperactivity after TBI manifests as catecholamine excess, hypertension, abnormal heart rate variability, and agitation, and is associated with poor neuropsychological outcome. Propranolol and clonidine are centrally acting drugs that may decrease sympathetic outflow, brain edema, and agitation. However, there is no prospective randomized evidence available demonstrating the feasibility, outcome benefits, and safety for adrenergic blockade after TBI. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 2% |
Japan | 1 | <1% |
United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Unknown | 201 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 31 | 15% |
Student > Master | 27 | 13% |
Student > Doctoral Student | 21 | 10% |
Other | 17 | 8% |
Student > Bachelor | 17 | 8% |
Other | 41 | 20% |
Unknown | 54 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 82 | 39% |
Psychology | 16 | 8% |
Nursing and Health Professions | 11 | 5% |
Neuroscience | 11 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 3% |
Other | 22 | 11% |
Unknown | 59 | 28% |