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Mendeley readers
Attention Score in Context
| Title |
Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study
|
|---|---|
| Published in |
Journal of Neural Transmission, August 2014
|
| DOI | 10.1007/s00702-014-1293-0 |
| Pubmed ID | |
| Authors |
Pascal F. Durrenberger, Francesca S. Fernando, Samira N. Kashefi, Tim P. Bonnert, Danielle Seilhean, Brahim Nait-Oumesmar, Andrea Schmitt, Peter J. Gebicke-Haerter, Peter Falkai, Edna Grünblatt, Miklos Palkovits, Thomas Arzberger, Hans Kretzschmar, David T. Dexter, Richard Reynolds |
| Abstract |
Neurodegenerative diseases of the central nervous system are characterized by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal populations. Despite exhibiting different clinical profiles and selective neuronal loss, common features such as abnormal protein deposition, dysfunctional cellular transport, mitochondrial deficits, glutamate excitotoxicity, iron accumulation and inflammation are observed in many neurodegenerative disorders, suggesting converging pathways of neurodegeneration. We have generated comparative genome-wide gene expression data, using the Illumina HumanRef 8 Beadchip, for Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, multiple sclerosis, Parkinson's disease, and schizophrenia using an extensive cohort (n = 113) of well-characterized post-mortem brain tissues. The analysis of whole-genome expression patterns across these major disorders offers an outstanding opportunity not only to look into exclusive disease-specific changes, but more importantly to look for potential common molecular pathogenic mechanisms. Surprisingly, no dysregulated gene that passed our selection criteria was found in common across all six diseases. However, 61 dysregulated genes were shared when comparing five and four diseases. The few genes highlighted by our direct gene comparison analysis hint toward common neuronal homeostatic, survival and synaptic plasticity pathways. In addition, we report changes to several inflammation-related genes in all diseases. This work is supportive of a general role of the innate immune system in the pathogenesis and/or response to neurodegeneration. |
Mendeley readers
The data shown below were compiled from readership statistics for 206 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 200 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 38 | 18% |
| Researcher | 32 | 16% |
| Student > Master | 32 | 16% |
| Student > Bachelor | 15 | 7% |
| Student > Doctoral Student | 11 | 5% |
| Other | 37 | 18% |
| Unknown | 41 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 35 | 17% |
| Neuroscience | 32 | 16% |
| Agricultural and Biological Sciences | 26 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 8% |
| Psychology | 13 | 6% |
| Other | 33 | 16% |
| Unknown | 51 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#3,505,721
of 24,393,299 outputs
Outputs from Journal of Neural Transmission
#251
of 1,873 outputs
Outputs of similar age
#34,747
of 235,913 outputs
Outputs of similar age from Journal of Neural Transmission
#5
of 30 outputs
Altmetric has tracked 24,393,299 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,873 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 235,913 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 30 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.