Title |
Apoptins: selective anticancer agents
|
---|---|
Published in |
Trends in Molecular Medicine, August 2014
|
DOI | 10.1016/j.molmed.2014.07.003 |
Pubmed ID | |
Authors |
Oscar M. Rollano Peñaloza, Magdalena Lewandowska, Joerg Stetefeld, Karolina Ossysek, Mariusz Madej, Joanna Bereta, Mateusz Sobczak, Shahla Shojaei, Saeid Ghavami, Marek J. Łos |
Abstract |
Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 50% |
United Kingdom | 1 | 25% |
Turkey | 1 | 25% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 25% |
Scientists | 1 | 25% |
Science communicators (journalists, bloggers, editors) | 1 | 25% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 4% |
Unknown | 49 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 9 | 18% |
Researcher | 6 | 12% |
Professor > Associate Professor | 6 | 12% |
Student > Ph. D. Student | 6 | 12% |
Student > Bachelor | 5 | 10% |
Other | 11 | 22% |
Unknown | 8 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 15 | 29% |
Biochemistry, Genetics and Molecular Biology | 8 | 16% |
Chemistry | 4 | 8% |
Medicine and Dentistry | 4 | 8% |
Engineering | 2 | 4% |
Other | 6 | 12% |
Unknown | 12 | 24% |