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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Novel Role for hSMG-1 in Stress Granule Formation
|
|---|---|
| Published in |
Molecular & Cellular Biology, March 2023
|
| DOI | 10.1128/mcb.05987-11 |
| Pubmed ID | |
| Authors |
James A. L. Brown, Tara L. Roberts, Renee Richards, Rick Woods, Geoff Birrell, Y. C. Lim, Shigeo Ohno, Akio Yamashita, Robert T. Abraham, Nuri Gueven, Martin F. Lavin |
| Abstract |
hSMG-1 is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family with established roles in nonsense-mediated decay (NMD) of mRNA containing premature termination codons and in genotoxic stress responses to DNA damage. We report here a novel role for hSMG-1 in cytoplasmic stress granule (SG) formation. Exposure of cells to stress causing agents led to the localization of hSMG-1 to SG, identified by colocalization with TIA-1, G3BP1, and eIF4G. hSMG-1 small interfering RNA and the PIKK inhibitor wortmannin prevented formation of a subset of SG, while specific inhibitors of ATM, DNA-PK(cs), or mTOR had no effect. Exposure of cells to H(2)O(2) and sodium arsenite induced (S/T)Q phosphorylation of proteins. While Upf2 and Upf1, an essential substrate for hSMG-1 in NMD, were present in SG, NMD-specific Upf1 phosphorylation was not detected in SG, indicating hSMG-1's role in SG is separate from classical NMD. Thus, SG formation appears more complex than originally envisaged and hSMG-1 plays a central role in this process. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| United States | 1 | 1% |
| Canada | 1 | 1% |
| Switzerland | 1 | 1% |
| Unknown | 83 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 24% |
| Student > Ph. D. Student | 20 | 23% |
| Student > Master | 10 | 11% |
| Professor | 7 | 8% |
| Student > Doctoral Student | 6 | 7% |
| Other | 9 | 10% |
| Unknown | 15 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 40% |
| Biochemistry, Genetics and Molecular Biology | 27 | 31% |
| Neuroscience | 4 | 5% |
| Philosophy | 2 | 2% |
| Medicine and Dentistry | 2 | 2% |
| Other | 1 | 1% |
| Unknown | 17 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 August 2017.
All research outputs
#7,960,052
of 25,374,647 outputs
Outputs from Molecular & Cellular Biology
#4,104
of 11,892 outputs
Outputs of similar age
#140,279
of 421,778 outputs
Outputs of similar age from Molecular & Cellular Biology
#3,120
of 8,975 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 11,892 research outputs from this source. They receive a mean Attention Score of 4.5. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,778 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 8,975 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.