Title |
Reduced levels of hydroxylated, polyunsaturated ultra long-chain fatty acids in the serum of colorectal cancer patients: implications for early screening and detection
|
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Published in |
BMC Medicine, February 2010
|
DOI | 10.1186/1741-7015-8-13 |
Pubmed ID | |
Authors |
Shawn A Ritchie, Pearson WK Ahiahonu, Dushmanthi Jayasinghe, Doug Heath, Jun Liu, Yingshen Lu, Wei Jin, Amir Kavianpour, Yasuyo Yamazaki, Amin M Khan, Mohammad Hossain, Khine Khine Su-Myat, Paul L Wood, Kevin Krenitsky, Ichiro Takemasa, Masakazu Miyake, Mitsugu Sekimoto, Morito Monden, Hisahiro Matsubara, Fumio Nomura, Dayan B Goodenowe |
Abstract |
There are currently no accurate serum markers for detecting early risk of colorectal cancer (CRC). We therefore developed a non-targeted metabolomics technology to analyse the serum of pre-treatment CRC patients in order to discover putative metabolic markers associated with CRC. Using tandem-mass spectrometry (MS/MS) high throughput MS technology we evaluated the utility of selected markers and this technology for discriminating between CRC and healthy subjects. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | <1% |
United States | 1 | <1% |
Unknown | 185 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 51 | 27% |
Student > Ph. D. Student | 32 | 17% |
Researcher | 27 | 14% |
Student > Master | 11 | 6% |
Professor > Associate Professor | 7 | 4% |
Other | 24 | 13% |
Unknown | 35 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 36 | 19% |
Chemistry | 25 | 13% |
Medicine and Dentistry | 22 | 12% |
Biochemistry, Genetics and Molecular Biology | 18 | 10% |
Engineering | 9 | 5% |
Other | 36 | 19% |
Unknown | 41 | 22% |