Title |
A scientific paradigm for targeted nanophotothermolysis; the potential for nanosurgery of cancer
|
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Published in |
Lasers in Medical Science, August 2013
|
DOI | 10.1007/s10103-013-1399-x |
Pubmed ID | |
Authors |
Ali Shakeri-Zadeh, Seyed Kamran Kamrava, Mohammad Farhadi, Zahra Hajikarimi, Shayan Maleki, Amirhossein Ahmadi |
Abstract |
The application of gold nanoparticles (AuNPs) in nanophotothermolysis as a great photosensitizer is expanding, and this subject is a challenging area for cancer therapy. Recent technological advances in nanoscale manufacturing and synthesis promise the development of highly beneficial and innovative methods for the targeting of cancer. However, there is an obstacle to conducting effective laser-based nanosurgery because AuNPs are activated by visible or near infrared wavelengths, and the penetration of a laser beam inside the body is limited by some absorbents, such as melanin, water, and blood molecules. Considering everything stated above, we have suggested the application of a folate-conjugated AuNP as an effective agent for targeted nanophotothermolysis and the application of an optical fiber to transport the laser light from the source to the target tissue inside the body. Thus, a new method of nanosurgery in which a surgeon is able to perform surgery at the cellular or even at the subcellular level may be possible. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 28 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 21% |
Researcher | 4 | 14% |
Student > Bachelor | 2 | 7% |
Student > Master | 2 | 7% |
Student > Doctoral Student | 1 | 4% |
Other | 4 | 14% |
Unknown | 9 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 21% |
Chemistry | 3 | 11% |
Engineering | 3 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Materials Science | 2 | 7% |
Other | 4 | 14% |
Unknown | 8 | 29% |