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Multi-layered global gene regulation in mouse embryonic stem cells

Overview of attention for article published in Cellular and Molecular Life Sciences, September 2014
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

blogs
1 blog
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3 X users

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38 Mendeley
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Title
Multi-layered global gene regulation in mouse embryonic stem cells
Published in
Cellular and Molecular Life Sciences, September 2014
DOI 10.1007/s00018-014-1734-9
Pubmed ID
Authors

Samuel Beck, Bum-Kyu Lee, Jonghwan Kim

Abstract

Embryonic stem (ES) cells derived from the inner cell mass of developing embryos have tremendous potential in regenerative medicine due to their unique properties: ES cells can be maintained for a prolonged time without changes in their cellular characteristics in vitro (self-renewal), while sustaining the capacity to give rise to all cell types of adult organisms (pluripotency). In addition to the development of protocols to manipulate ES cells for therapeutic applications, understanding how such unique properties are maintained has been one of the key questions in stem cell research. During the past decade, advances in high-throughput technologies have enabled us to systematically monitor multiple layers of gene regulatory mechanisms in ES cells. In this review, we briefly summarize recent findings on global gene regulatory modes in ES cells, mainly focusing on the regulatory factors responsible for transcriptional and epigenetic regulations as well as their modular regulatory patterns throughout the genome.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 38 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 5%
United Kingdom 1 3%
Iran, Islamic Republic of 1 3%
Unknown 34 89%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 24%
Student > Ph. D. Student 9 24%
Student > Master 7 18%
Professor > Associate Professor 3 8%
Student > Bachelor 3 8%
Other 2 5%
Unknown 5 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 16 42%
Biochemistry, Genetics and Molecular Biology 13 34%
Immunology and Microbiology 1 3%
Medicine and Dentistry 1 3%
Neuroscience 1 3%
Other 2 5%
Unknown 4 11%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2015.
All research outputs
#4,104,544
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#723
of 4,151 outputs
Outputs of similar age
#42,425
of 251,107 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#7
of 52 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 82nd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 251,107 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 52 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.