@ENirenberg @chackettwrites Yes the role of glycoforms of the same antibodies is critically important to functional outcomes. We explored this in human in-vivo experiments with RBCs coated with two versions of the same IgG1 anti-D antibody. https://t.co/el
There is also a relevance to use of recombinant antibodies for therapy. The same antibody expressed in different expression systems can have markedly different biological effects in vivo as we discovered for an anti-RhD Ab for possible treatment of HDN htt
Clearance of Human IgG1-Sensitised Red Blood Cells In Vivo in Humans Relates to the In Vitro Properties of… http://t.co/Nir65xSqat