Title |
Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα
|
---|---|
Published in |
Cell Reports, October 2014
|
DOI | 10.1016/j.celrep.2014.09.025 |
Pubmed ID | |
Authors |
Eugenia Morselli, Esther Fuente-Martin, Brian Finan, Min Kim, Aaron Frank, Cristina Garcia-Caceres, Carlos Rodriguez Navas, Ruth Gordillo, Michael Neinast, Sarada P. Kalainayakan, Dan L. Li, Yuanqing Gao, Chun-Xia Yi, Lisa Hahner, Biff F. Palmer, Matthias H. Tschöp, Deborah J. Clegg |
Abstract |
High-fat diets (HFDs) lead to obesity and inflammation in the central nervous system (CNS). Estrogens and estrogen receptor α (ERα) protect premenopausal females from the metabolic complications of inflammation and obesity-related disease. Here, we demonstrate that hypothalamic PGC-1α regulates ERα and inflammation in vivo. HFD significantly increased palmitic acid (PA) and sphingolipids in the CNS of male mice when compared to female mice. PA, in vitro, and HFD, in vivo, reduced PGC-1α and ERα in hypothalamic neurons and astrocytes of male mice and promoted inflammation. PGC-1α depletion with ERα overexpression significantly inhibited PA-induced inflammation, confirming that ERα is a critical determinant of the anti-inflammatory response. Physiologic relevance of ERα-regulated inflammation was demonstrated by reduced myocardial function in male, but not female, mice following chronic HFD exposure. Our findings show that HFD/PA reduces PGC-1α and ERα, promoting inflammation and decrements in myocardial function in a sex-specific way. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 3 | 10% |
United States | 3 | 10% |
France | 2 | 6% |
Netherlands | 2 | 6% |
Brazil | 1 | 3% |
Myanmar | 1 | 3% |
Canada | 1 | 3% |
United Kingdom | 1 | 3% |
Unknown | 17 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 25 | 81% |
Practitioners (doctors, other healthcare professionals) | 4 | 13% |
Science communicators (journalists, bloggers, editors) | 1 | 3% |
Scientists | 1 | 3% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Unknown | 176 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 38 | 21% |
Researcher | 30 | 17% |
Student > Master | 22 | 12% |
Student > Bachelor | 21 | 12% |
Other | 10 | 6% |
Other | 31 | 17% |
Unknown | 27 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 47 | 26% |
Biochemistry, Genetics and Molecular Biology | 37 | 21% |
Neuroscience | 26 | 15% |
Medicine and Dentistry | 15 | 8% |
Nursing and Health Professions | 9 | 5% |
Other | 18 | 10% |
Unknown | 27 | 15% |