Title |
The anti-adhesive mode of action of a purified mushroom (Lentinus edodes) extract with anticaries and antigingivitis properties in two oral bacterial pathogens
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Published in |
BMC Complementary Medicine and Therapies, February 2014
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DOI | 10.1186/1472-6882-14-75 |
Pubmed ID | |
Authors |
Caterina Signoretto, Anna Marchi, Anna Bertoncelli, Gloria Burlacchini, Adele Papetti, Carla Pruzzo, Egija Zaura, Peter Lingström, Itzhak Ofek, Jonathan Pratten, David A Spratt, Michael Wilson, Pietro Canepari |
Abstract |
In previous works we have shown that a low-molecular-mass (LMM) fraction from mushroom (Lentinus edodes) homogenate interferes with binding of Streptococcus mutans to hydroxyapatite and Prevotella intermedia to gingival cells. Additionally, inhibition of biofilm formation of both odonto- and periodonto-pathogenic bacteria and detachment from preformed biofilms have been described for this compound. Further purification of mushroom extract has been recently achieved and a sub-fraction (i.e. # 5) has been identified as containing the majority of the mentioned biological activities. The aim of this study was to characterise the bacterial receptors for the purified mushroom sub-fraction #5 in order to better elucidate the mode of action of this compound when interfering with bacterial adhesion to host surfaces or with bacteria-bacteria interactions in the biofilm state. |
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Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
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Japan | 1 | 2% |
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Student > Master | 8 | 15% |
Lecturer | 5 | 9% |
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Student > Bachelor | 4 | 7% |
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Social Sciences | 1 | 2% |
Other | 3 | 5% |
Unknown | 23 | 42% |