Title |
miR-103/107 modulates multidrug resistance in human gastric carcinoma by downregulating Cav-1
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Published in |
Tumor Biology, November 2014
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DOI | 10.1007/s13277-014-2835-7 |
Pubmed ID | |
Authors |
Ye Zhang, Xiujuan Qu, Ce Li, Yibo Fan, Xiaofang Che, Ximing Wang, Ying Cai, Xuejun Hu, Yunpeng Liu |
Abstract |
MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In the present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR and its parent cell line SGC7901 using a miRNA microarray. MiR-103/107 was downregulated compared with parental SGC7901 cells. Overexpression of miR-103/107 sensitized SGC7901/ADR cells to doxorubicin (DOX), as demonstrated by in vitro and in vivo drug sensitivity assay. We further confirmed that miR-103/107 inhibited P-gp function in gastric cancer SGC7901/ADR cells. Finally, we verified that caveolin-1 (Cav-1), a critical component of lipid rafts, was a target of miR-103/107. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 1 | 4% |
Unknown | 25 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 4 | 15% |
Student > Ph. D. Student | 3 | 12% |
Student > Postgraduate | 3 | 12% |
Student > Master | 3 | 12% |
Student > Bachelor | 2 | 8% |
Other | 4 | 15% |
Unknown | 7 | 27% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 7 | 27% |
Medicine and Dentistry | 6 | 23% |
Agricultural and Biological Sciences | 3 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
Unknown | 9 | 35% |