"IL-6, when endogenously released during systemic inflammation, is pyrogenic by binding to IL-6Rα on brain endothelial cells to induce prostaglandin [...] probably in concerted action with other peripherally released cytokines" https://t.co/G4EWcU6cT8 http
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@delysis @jack_meditates @selentelechia And I bet you would love to hear about the role of IL-6 mediated neuroinflammation in... literally every disease causing a fever. https://t.co/YsHAMXIgrj That is because CNS IL-6 *is the mechanism for causing fever
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Adap: Immune-induced fever is mediated by IL-6 receptors on brain endothelial cells coupled to STAT3-dependent… http://t.co/xlVGgsfxU5
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Cyt: Immune-Induced Fever Is Mediated by IL-6 Receptors on Brain Endothelial Cells Coupled to STAT3-Dependent… http://t.co/PlFoTOQ00u