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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Deep TMS of the insula using the H-coil modulates dopamine release: a crossover [11C] PHNO-PET pilot trial in healthy humans
|
|---|---|
| Published in |
Brain Imaging and Behavior, November 2017
|
| DOI | 10.1007/s11682-017-9800-1 |
| Pubmed ID | |
| Authors |
Saima Malik, Mark Jacobs, Sang-Soo Cho, Isabelle Boileau, Daniel Blumberger, Markus Heilig, Alan Wilson, Zafiris J. Daskalakis, Antonio P. Strafella, Abraham Zangen, Bernard Le Foll |
| Abstract |
Modulating the function of the insular cortex could be a novel therapeutic strategy to treat addiction to a variety of drugs of abuse as this region has been implicated in mediating drug reward and addictive processes. The recent advent of the H-coil has permitted the targeting of deeper brain structures which was not previously feasible. The goal of this study was to bilaterally target the insular region using the H-coil with repetitive Transcranial Magnetic Stimulation (rTMS) and subsequently measure changes in dopamine levels using Positron Emission Tomography (PET) with [11C]-(+)-propyl-hexahydro-naphtho-oxazin (PHNO). This was a within-subject, crossover, blinded and sham-controlled pilot study. Eight healthy, right-handed subjects, aged 19-45, participated in the investigation. All subjects underwent 3 PHNO-PET scans preceded by rTMS (sham, 1 Hz or 10 Hz), on 3 separate days. Low frequency rTMS (1 Hz), targeting the insular cortex, significantly decreased dopamine levels in the substantia nigra, sensorimotor striatum and associative striatum. Replicating this study in tobacco smokers or alcoholics would be a logical follow-up to assess whether H-coil stimulation of the bilateral insula can be employed as a treatment option for addiction. NCT02212405. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 22% |
| Australia | 1 | 11% |
| Grenada | 1 | 11% |
| France | 1 | 11% |
| United Kingdom | 1 | 11% |
| Unknown | 3 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 56% |
| Members of the public | 4 | 44% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 115 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 16% |
| Student > Bachelor | 12 | 10% |
| Researcher | 11 | 10% |
| Student > Master | 10 | 9% |
| Student > Doctoral Student | 9 | 8% |
| Other | 28 | 24% |
| Unknown | 27 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 29 | 25% |
| Psychology | 18 | 16% |
| Medicine and Dentistry | 11 | 10% |
| Engineering | 7 | 6% |
| Nursing and Health Professions | 4 | 3% |
| Other | 12 | 10% |
| Unknown | 34 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2017.
All research outputs
#6,718,942
of 24,143,470 outputs
Outputs from Brain Imaging and Behavior
#353
of 1,175 outputs
Outputs of similar age
#127,022
of 445,886 outputs
Outputs of similar age from Brain Imaging and Behavior
#5
of 25 outputs
Altmetric has tracked 24,143,470 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,175 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,886 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.