Title |
Diverse Roles for T-bet in the Effector Responses Required for Resistance to Infection
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Published in |
The Journal of Immunology, February 2015
|
DOI | 10.4049/jimmunol.1401617 |
Pubmed ID | |
Authors |
Gretchen Harms Pritchard, Aisling O'Hara Hall, David A Christian, Sagie Wagage, Qun Fang, Gaia Muallem, Beena John, Arielle Glatman Zaretsky, William G Dunn, Jacqueline Perrigoue, Steven L Reiner, Christopher A Hunter |
Abstract |
The transcription factor T-bet has been most prominently linked to NK and T cell production of IFN-γ, a cytokine required for the control of a diverse array of intracellular pathogens. Indeed, in mice challenged with the parasite Toxoplasma gondii, NK and T cell responses are characterized by marked increases of T-bet expression. Unexpectedly, T-bet(-/-) mice infected with T. gondii develop a strong NK cell IFN-γ response that controls parasite replication at the challenge site, but display high parasite burdens at secondary sites colonized by T. gondii and succumb to infection. The loss of T-bet had a modest effect on T cell production of IFN-γ but did not impact on the generation of parasite-specific T cells. However, the absence of T-bet resulted in lower T cell expression of CD11a, Ly6C, KLRG-1, and CXCR3 and fewer parasite-specific T cells at secondary sites of infection, associated with a defect in parasite control at these sites. Together, these data highlight T-bet-independent pathways to IFN-γ production and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control this infection in peripheral tissues. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Mexico | 1 | 2% |
United States | 1 | 2% |
Germany | 1 | 2% |
Belgium | 1 | 2% |
Unknown | 49 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 14 | 26% |
Researcher | 10 | 19% |
Student > Master | 9 | 17% |
Student > Doctoral Student | 6 | 11% |
Student > Bachelor | 3 | 6% |
Other | 6 | 11% |
Unknown | 5 | 9% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 18 | 34% |
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Medicine and Dentistry | 8 | 15% |
Biochemistry, Genetics and Molecular Biology | 2 | 4% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 8% |
Unknown | 8 | 15% |