Title |
Universal Sharing Patterns in Proteomes and Evolution of Protein Fold Architecture and Life
|
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Published in |
Journal of Molecular Evolution, April 2005
|
DOI | 10.1007/s00239-004-0221-6 |
Pubmed ID | |
Authors |
Gustavo Caetano-Anollés, Derek Caetano-Anollés |
Abstract |
Protein evolution is imprinted in both the sequence and the structure of evolutionary building blocks known as protein domains. These domains share a common ancestry and can be unified into a comparatively small set of folding architectures, the protein folds. We have traced the distribution of protein folds between and within proteomes belonging to Eukarya, Archaea, and Bacteria along the branches of a universal phylogeny of protein architecture. This tree was reconstructed from global fold-usage statistics derived from a structural census of proteomes. We found that folds shared by the three organismal domains were placed almost exclusively at the base of the rooted tree and that there were marked heterogeneities in fold distribution and clear evolutionary patterns related to protein architecture and organismal diversification. These include a relative timing for the emergence of prokaryotes, congruent episodes of architectural loss and diversification in Archaea and Bacteria, and a late and quite massive rise of architectural novelties in Eukarya perhaps linked to multicellularity. |
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Geographical breakdown
Country | Count | As % |
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Germany | 2 | 5% |
Chile | 1 | 3% |
Italy | 1 | 3% |
Mexico | 1 | 3% |
Spain | 1 | 3% |
Unknown | 31 | 84% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 27% |
Student > Ph. D. Student | 9 | 24% |
Professor | 4 | 11% |
Professor > Associate Professor | 3 | 8% |
Student > Master | 3 | 8% |
Other | 7 | 19% |
Unknown | 1 | 3% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 54% |
Biochemistry, Genetics and Molecular Biology | 8 | 22% |
Computer Science | 4 | 11% |
Mathematics | 1 | 3% |
Philosophy | 1 | 3% |
Other | 2 | 5% |
Unknown | 1 | 3% |