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X Demographics
Mendeley readers
Attention Score in Context
| Title |
5HTT is associated with the phenotype psychological flexibility: results from a randomized clinical trial
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, January 2015
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| DOI | 10.1007/s00406-015-0575-3 |
| Pubmed ID | |
| Authors |
Andrew T. Gloster, Alexander L. Gerlach, Alfons Hamm, Michael Höfler, Georg W. Alpers, Tilo Kircher, Andreas Ströhle, Thomas Lang, Hans-Ulrich Wittchen, Jürgen Deckert, Andreas Reif |
| Abstract |
Adaption to changing environments is evolutionarily advantageous. Studies that link genetic and phenotypic expression of flexible adjustment to one's context are largely lacking. In this study, we tested the importance of psychological flexibility, or goal-related context sensitivity, in an interaction between psychotherapy outcome for panic disorder with agoraphobia (PD/AG) and a genetic polymorphism. Given the established role of the 5HTT-LPR polymorphism in behavioral flexibility, we tested whether this polymorphism (short group vs. long group) impacted therapy response as a function of various endophenotypes (i.e., psychological flexibility, panic, agoraphobic avoidance, and anxiety sensitivity). Patients with PD/AG were recruited from a large multicenter randomized controlled clinical trial on cognitive-behavioral therapy. Pre- to post-treatment changes by 5HTT polymorphism were analyzed. 5HTT polymorphism status differentiated pre- to post-treatment changes in the endophenotype psychological flexibility (effect size difference d = 0.4, p < 0.05), but none of the specific symptom-related endophenotypes consistently for both the intent-to-treat sample (n = 228) and the treatment completers (n = 194). Based on the consistency of these findings with existing theory on behavioral flexibility, the specificity of the results across phenotypes, and the consistency of results across analyses (i.e., completer and intent to treat), we conclude that 5HTT polymorphism and the endophenotype psychological flexibility are important variables for the treatment of PD/AG. The endophenotype psychological flexibility may help bridge genetic and psychological literatures. Despite the limitation of the post hoc nature of these analyses, further study is clearly warranted. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 93 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 17 | 18% |
| Student > Ph. D. Student | 13 | 14% |
| Researcher | 12 | 13% |
| Professor | 9 | 9% |
| Student > Bachelor | 8 | 8% |
| Other | 15 | 16% |
| Unknown | 21 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 50 | 53% |
| Medicine and Dentistry | 10 | 11% |
| Neuroscience | 3 | 3% |
| Nursing and Health Professions | 2 | 2% |
| Social Sciences | 1 | 1% |
| Other | 3 | 3% |
| Unknown | 26 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 February 2015.
All research outputs
#16,049,105
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#839
of 1,243 outputs
Outputs of similar age
#230,760
of 384,368 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#8
of 15 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 384,368 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.