Title |
Endocrine disrupters and pubertal timing
|
---|---|
Published in |
Current Opinion in Endocrinology Diabetes and Obesity, February 2018
|
DOI | 10.1097/med.0000000000000377 |
Pubmed ID | |
Authors |
Louise C Greenspan, Mary M Lee |
Abstract |
The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing. In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty. The effects of EDCs on pubertal timing are sexually dimorphic, compound specific, and varies according to the window of exposure. These studies confirm that low-level exposures to a mix of environmental compounds may mask the effects of individual compounds and complicate our ability to translate data from animal studies to human health and to fully understand the clinical implications of environmental epidemiology studies. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 40% |
Unknown | 3 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 63 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 13% |
Student > Ph. D. Student | 7 | 11% |
Researcher | 6 | 10% |
Student > Doctoral Student | 5 | 8% |
Lecturer | 5 | 8% |
Other | 8 | 13% |
Unknown | 24 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 14% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Environmental Science | 4 | 6% |
Social Sciences | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
Other | 9 | 14% |
Unknown | 28 | 44% |