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Mendeley readers
Attention Score in Context
| Title |
DARPP-32 mediates the actions of multiple drugs of abuse
|
|---|---|
| Published in |
The AAPS Journal, October 2005
|
| DOI | 10.1208/aapsj070235 |
| Pubmed ID | |
| Authors |
Per Svenningsson, Angus C. Nairn, Paul Greengard |
| Abstract |
Drugs of abuse share the ability to enhance dopaminergic neurotransmission in the dorsal and ventral striatum. The action of dopamine is modulated by additional neurotransmitters, including glutamate, serotonin and adenosine. All these neurotransmitters regulate the phosphorylation state of Dopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32). Phosphorylation at Thr(34) by protein kinase A converts DARPP-32 into a potent inhibitor of the multifunctional serine/threonine protein phosphatase, PP-1. Phosphorylation at Thr(75) by Cdk5 converts DARPP-32 into an inhibitor of protein kinase A. The state of phosphorylation of DARPP-32 at Thr(34) also depends on the phosphorylation state of Ser(97) and Ser(130), which are phosphorylated by CK2 and CK1, respectively. By virtue of regulation of these 4 phosphorylation sites, and through its ability to modulate the activity of PP-1 and protein kinase A, DARPP-32 plays a key role in integrating a variety of biochemical, electrophysiological, and behavioral responses controlled by dopamine and other neurotransmitters. Importantly, there is now a large body of evidence that supports a key role for DARPP-32-dependent signaling in mediating the actions of multiple drugs of abuse including cocaine, amphetamine, nicotine, caffeine, LSD, PCP, ethanol and morphine. |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 4% |
| Canada | 2 | 2% |
| United Kingdom | 1 | <1% |
| Brazil | 1 | <1% |
| Iran, Islamic Republic of | 1 | <1% |
| South Africa | 1 | <1% |
| Unknown | 110 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 26% |
| Researcher | 23 | 19% |
| Student > Bachelor | 10 | 8% |
| Professor > Associate Professor | 10 | 8% |
| Student > Master | 8 | 7% |
| Other | 23 | 19% |
| Unknown | 15 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 52 | 43% |
| Neuroscience | 19 | 16% |
| Medicine and Dentistry | 9 | 7% |
| Psychology | 7 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 3% |
| Other | 7 | 6% |
| Unknown | 23 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 March 2009.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from The AAPS Journal
#520
of 1,463 outputs
Outputs of similar age
#25,364
of 71,151 outputs
Outputs of similar age from The AAPS Journal
#14
of 27 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,463 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,151 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.