Dipeptide Repeat Proteins Trigger TDP-43 Pathology, Faulty Nuclear Import
Alzforum,
05 Oct 2018 How do expanded hexanucleotide repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis and frontotemporal…
No, TDP-43 and FUS Are Not Actively Exported From the Nucleus
Alzforum,
18 May 2018 In amyotrophic lateral sclerosis and frontotemporal dementia, the nuclear RNA-binding proteins TDP-43 and FUS…
TDP-43 Snarls Nuclear Traffic
Alzforum,
17 Jan 2018 Many proteins linked to neurodegeneration impede traffic in and out of the nucleus, and in the January 8 Nature…
Cellular Traffic Jam Seen in ALS/FTD
Drug Discovery and Development ,
A cellular traffic jam appears to affect neurons in most forms of ALS (amyotrophic lateral sclerosis), researchers at Emory…