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Attention Score in Context
| Title |
Inactivation status of PCDH11X: sexual dimorphisms in gene expression levels in brain
|
|---|---|
| Published in |
Human Genetics, January 2006
|
| DOI | 10.1007/s00439-006-0134-0 |
| Pubmed ID | |
| Authors |
Alexandra M. Lopes, Norman Ross, James Close, Adam Dagnall, António Amorim, Timothy J. Crow |
| Abstract |
Genes escaping X-inactivation are predicted to contribute to differences in gene dosage between the sexes and are the prime candidates for being involved in the phenotype observed in individuals with X chromosome aneuploidies. Of particular interest is ProtocadherinX (PCDH11X or PCDHX), a recently described gene expressed in brain. In humans, PCDH11X has a homologue on the Y chromosome and is predicted to escape from X-inactivation. Employing bisulphite sequencing analysis we found absence of CpG island methylation on both the active and the inactive X chromosomes, providing a strong indication that PCDH11X escapes inactivation in humans. Furthermore, a sexual dimorphism in levels of expression in brain tissue was observed by quantitative real-time PCR, with females presenting an up to 2-fold excess in the abundance of PCDH11X transcripts. We relate these findings to sexually dimorphic traits in the human brain. Interestingly, PCDH11X/Y gene pair is unique to Homo sapiens, since the X-linked gene was transposed to the Y chromosome after the human-chimpanzee lineages split. Although no differences in promoter methylation were found between humans and chimpanzees, evidence of an upregulation of PCDH11X in humans deserves further investigation. |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Portugal | 1 | 3% |
| Unknown | 29 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 32% |
| Professor | 6 | 19% |
| Student > Ph. D. Student | 5 | 16% |
| Student > Bachelor | 3 | 10% |
| Student > Master | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 3 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 14 | 45% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Psychology | 3 | 10% |
| Social Sciences | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Other | 4 | 13% |
| Unknown | 3 | 10% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2021.
All research outputs
#7,451,584
of 22,780,967 outputs
Outputs from Human Genetics
#933
of 2,951 outputs
Outputs of similar age
#40,751
of 155,540 outputs
Outputs of similar age from Human Genetics
#7
of 18 outputs
Altmetric has tracked 22,780,967 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,951 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,540 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.