Title |
Role of the 5-HT7 Receptor in the Central Nervous System: from Current Status to Future Perspectives
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Published in |
Molecular Neurobiology, March 2011
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DOI | 10.1007/s12035-011-8175-3 |
Pubmed ID | |
Authors |
Anne Matthys, Guy Haegeman, Kathleen Van Craenenbroeck, Peter Vanhoenacker |
Abstract |
Pharmacological and genetic tools targeting the 5-hydroxytryptamine (5-HT)7 receptor in preclinical animal models have implicated this receptor in diverse (patho)physiological processes of the central nervous system (CNS). Some data obtained with 5-HT7 receptor knockout mice, selective antagonists, and, to a lesser extent, agonists, however, are quite contradictory. In this review, we not only discuss in detail the role of the 5-HT7 receptor in the CNS but also propose some hypothetical models, which could explain the observed inconsistencies. These models are based on two novel concepts within the field of G protein-coupled receptors (GPCR), namely biphasic signaling and G protein-independent signaling, which both have been shown to be mediated by GPCR dimerization. This led us to suggest that the 5-HT7 receptor could reside in different dimeric contexts and initiate different signaling pathways, depending on the neuronal circuitry and/or brain region. In conclusion, we highlight GPCR dimerization and G protein-independent signaling as two promising future directions in 5-HT7 receptor research, which ultimately might lead to the development of more efficient dimer- and/or pathway-specific therapeutics. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | 3% |
United Kingdom | 2 | 1% |
Poland | 2 | 1% |
Malta | 1 | <1% |
Germany | 1 | <1% |
Unknown | 132 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 28 | 20% |
Researcher | 20 | 14% |
Student > Master | 19 | 13% |
Student > Bachelor | 13 | 9% |
Other | 6 | 4% |
Other | 25 | 18% |
Unknown | 31 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 34 | 24% |
Medicine and Dentistry | 20 | 14% |
Neuroscience | 20 | 14% |
Chemistry | 12 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 11 | 8% |
Other | 15 | 11% |
Unknown | 30 | 21% |