Disease Gene Identification

Chapter 1 Identification of Disease Susceptibility Alleles in the Next Generation Sequencing Era

Chapter 2 Induced Pluripotent Stem Cells in Disease Modeling and Gene Identification

Chapter 3 Development of Targeted Therapies Based on Gene Modification

Chapter 4 What Can We Learn About Human Disease from the Nematode C. elegans?

Chapter 5 Microbiome Sequencing Methods for Studying Human Diseases

Chapter 6 The Emerging Role of Long Noncoding RNAs in Human Disease

Chapter 7 Identification of Disease-Related Genes Using a Genome-Wide Association Study Approach

Chapter 8 Whole Genome Library Construction for Next Generation Sequencing

Chapter 9 Whole Exome Library Construction for Next Generation Sequencing

Chapter 10 Optimized Methodology for the Generation of RNA-Sequencing Libraries from Low-Input Starting Material: Enabling Analysis of Specialized Cell Types and Clinical Samples

Chapter 11 Using Fluidigm C1 to Generate Single-Cell Full-Length cDNA Libraries for mRNA Sequencing

Chapter 12 MiSeq: A Next Generation Sequencing Platform for Genomic Analysis

Chapter 13 Methods for CpG Methylation Array Profiling Via Bisulfite Conversion

Chapter 14 miRNA Quantification Method Using Quantitative Polymerase Chain Reaction in Conjunction with C q Method

Chapter 15 Primary Airway Epithelial Cell Gene Editing Using CRISPR-Cas9

Chapter 16 RNA Interference to Knock Down Gene Expression

Chapter 17 Using Luciferase Reporter Assays to Identify Functional Variants at Disease-Associated Loci

Chapter 18 Physiologic Interpretation of GWAS Signals for Type 2 Diabetes

Chapter 19 Identification of Genes for Hereditary Hemochromatosis

Chapter 20 Identification of Driver Mutations in Rare Cancers: The Role of SMARCA4 in Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT)

Chapter 21 The Rise and Fall and Rise of Linkage Analysis as a Technique for Finding and Characterizing Inherited Influences on Disease Expression