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Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma

Overview of attention for article published in Annals of Hematology, February 2018
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Title
Geriatric nutritional risk index as a prognostic factor in patients with diffuse large B cell lymphoma
Published in
Annals of Hematology, February 2018
DOI 10.1007/s00277-018-3273-1
Pubmed ID
Authors

Yusuke Kanemasa, Tatsu Shimoyama, Yuki Sasaki, Tsunekazu Hishima, Yasushi Omuro

Abstract

The geriatric nutritional risk index (GNRI) is a simple and well-established nutritional assessment tool that is a significant prognostic factor for various cancers. However, the role of the GNRI in predicting clinical outcomes of diffuse large B cell lymphoma (DLBCL) patients has not been investigated. To address this issue, we retrospectively analyzed a total of 476 patients with newly diagnosed de novo DLBCL. We defined the best cutoff value of the GNRI as 96.8 using a receiver operating characteristic curve. Patients with a GNRI < 96.8 had significantly lower overall survival (OS) and progression-free survival (PFS) than those with a GNRI ≥ 96.8 (5-year OS, 61.2 vs. 84.4%, P < 0.001; 5-year PFS, 53.7 vs. 75.8%, P < 0.001). Multivariate analysis showed that performance status, Ann Arbor stage, serum lactate dehydrogenase, and GNRI were independent prognostic factors for OS. Among patients with high-intermediate and high-risk by National Comprehensive Cancer Network-International Prognostic Index (NCCN-IPI), the 5-year OS was significantly lower in patients with a GNRI < 96.8 than in those with a GNRI ≥ 96.8 (high-intermediate risk, 59.5 vs. 75.2%, P = 0.006; high risk, 37.4 vs. 64.9%, P = 0.033). In the present study, we demonstrated that the GNRI was an independent prognostic factor in DLBCL patients. The GNRI could identify a population of poor-risk patients among those with high-intermediate and high-risk by NCCN-IPI.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 4 13%
Student > Bachelor 4 13%
Lecturer 3 10%
Researcher 3 10%
Student > Ph. D. Student 3 10%
Other 7 23%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 14 45%
Nursing and Health Professions 5 16%
Pharmacology, Toxicology and Pharmaceutical Science 2 6%
Psychology 1 3%
Unknown 9 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 February 2018.
All research outputs
#18,587,406
of 23,023,224 outputs
Outputs from Annals of Hematology
#1,482
of 2,200 outputs
Outputs of similar age
#331,978
of 442,600 outputs
Outputs of similar age from Annals of Hematology
#27
of 52 outputs
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