Title |
Amyotrophic Lateral Sclerosis after Receiving the Human Papilloma Virus Vaccine: A Case Report of a 15-year-old Girl
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Published in |
Internal Medicine, February 2018
|
DOI | 10.2169/internalmedicine.0285-17 |
Pubmed ID | |
Authors |
Ryota Hikiami, Hodaka Yamakado, Shinsui Tatsumi, Takashi Ayaki, Yuichiro Hashi, Hirofumi Yamashita, Nobukatsu Sawamoto, Teruyuki Tsuji, Makoto Urushitani, Ryosuke Takahashi |
Abstract |
We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Japan | 33 | 21% |
United States | 7 | 4% |
Canada | 2 | 1% |
Germany | 1 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
Albania | 1 | <1% |
Colombia | 1 | <1% |
Other | 1 | <1% |
Unknown | 109 | 69% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 153 | 97% |
Scientists | 3 | 2% |
Practitioners (doctors, other healthcare professionals) | 2 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 29 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 21% |
Student > Master | 4 | 14% |
Student > Bachelor | 4 | 14% |
Student > Doctoral Student | 2 | 7% |
Lecturer | 1 | 3% |
Other | 3 | 10% |
Unknown | 9 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 21% |
Biochemistry, Genetics and Molecular Biology | 5 | 17% |
Neuroscience | 3 | 10% |
Nursing and Health Professions | 2 | 7% |
Immunology and Microbiology | 1 | 3% |
Other | 0 | 0% |
Unknown | 12 | 41% |