BRCAness/Homologous recombination repair defect signatures (SBS3 & ID6), a potential biomarker for PARPi response was believed to be a ubiquitous signature in pediatric tumors (check https://t.co/DXNOBiqb4G) 5/
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We reanalyzed the cohort from Gröbner, Worst et al, 2018 (https://t.co/DXNOBiqb4G) to identify COSMIC v3 Single-base substitutions (SBS) & small insertion & deletion signatures (ID) 2/ https://t.co/NilvoUt4Ub
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@DanaFarber KJ: Re cite https://t.co/ovAbUynhOL many genomic signatures in peds cancer are diff from adults and dont have molecular targeted therapy. Some are common with adults for which targeted therapy.
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@NCHforDocs EM: now citing https://t.co/ovAbUyETdl only 25 genes are tumor suppressors in peds cancers that overlap with adult genes.