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Advances in the understanding and treatment of human severe combined immunodeficiency

Overview of attention for article published in Immunologic Research, January 2000
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Title
Advances in the understanding and treatment of human severe combined immunodeficiency
Published in
Immunologic Research, January 2000
DOI 10.1385/ir:22:2-3:237
Pubmed ID
Authors

Rebecca H. Buckley

Abstract

Human severe combined immunodeficiency (SCID) can result from mutations in any one of at least seven different genes, including those for adenosine deaminase, the common cytokine receptor gamma chain, Janus kinase 3, IL-7 receptor alpha chain, recombinase activation genes 1 and 2, and CD45. Except for adenosine deaminase, knowledge concerning the latter causes of human SCID has accrued since 1993. Advances in the treatment of this syndrome have been no less significant. Since 1982 it has been possible, by rigorous depletion of T cells from the donor marrow, to use related marrow donors other than HLA-identical siblings for successful treatment of infants with this condition. The success rate with the latter type of transplant exceeds 95% if a transplant can be performed within the first 3.5 mo of life, making early diagnosis crucial. Recently, gene therapy has also been successful in infants with X-linked SCID.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 25 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 32%
Student > Ph. D. Student 4 16%
Student > Master 2 8%
Researcher 2 8%
Lecturer 1 4%
Other 5 20%
Unknown 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 16%
Biochemistry, Genetics and Molecular Biology 4 16%
Immunology and Microbiology 4 16%
Medicine and Dentistry 4 16%
Arts and Humanities 1 4%
Other 3 12%
Unknown 5 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2022.
All research outputs
#8,556,131
of 25,424,630 outputs
Outputs from Immunologic Research
#316
of 948 outputs
Outputs of similar age
#24,945
of 109,898 outputs
Outputs of similar age from Immunologic Research
#6
of 18 outputs
Altmetric has tracked 25,424,630 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 948 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.4. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 109,898 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.