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Mendeley readers
Attention Score in Context
| Title |
Magnetic Resonance Imaging of Human Brain Macrophage Infiltration
|
|---|---|
| Published in |
Neurotherapeutics, July 2007
|
| DOI | 10.1016/j.nurt.2007.05.005 |
| Pubmed ID | |
| Authors |
Klaus G. Petry, Claudine Boiziau, Vincent Dousset, Bruno Brochet |
| Abstract |
Macrophage tracking by magnetic resonance imaging (MRI) with iron oxide nanoparticles has been developed during the last decade for numerous diseases of the CNS. Experimental studies on animal models were confirmed by first clinical applications of MRI technology of brain macrophages for multiple sclerosis, ischemic stroke lesions, and tumors. As activated macrophages act in concert with other immune competent cells, this innovative MRI approach provides new functional data on the immune reaction in these CNS diseases. The MRI detection of brain macrophages defines precise spatial and temporal patterns of macrophage involvement that helps to characterize individual neurological disorders. This approach is being explored as an in vivo marker for the clinical diagnosis of cerebral lesion activity, in experimental models for the prognosis of disease development, and to determine the efficacy of immunomodulatory treatments under clinical evaluation. Comparative brain imaging follow-up studies of blood-brain barrier leakage by MRI with gadolinium-chelates, microglia activation by positron emission tomography with radiotracer ligand PK11195 and MRI detection of macrophage infiltration provide more precise information about the pathophysiological cascade of inflammatory events in cerebral diseases. Such multimodal characterization of the inflammatory events should help in the monitoring of patients, in defining precise time intervals for therapeutic interventions, and in developing and evaluating new therapeutic strategies. |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| United Kingdom | 1 | <1% |
| Canada | 1 | <1% |
| Japan | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 100 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 30% |
| Student > Ph. D. Student | 16 | 15% |
| Student > Bachelor | 10 | 10% |
| Professor > Associate Professor | 7 | 7% |
| Student > Master | 5 | 5% |
| Other | 17 | 16% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 30 | 29% |
| Agricultural and Biological Sciences | 13 | 12% |
| Neuroscience | 11 | 10% |
| Engineering | 5 | 5% |
| Computer Science | 4 | 4% |
| Other | 19 | 18% |
| Unknown | 23 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2021.
All research outputs
#8,543,833
of 25,394,764 outputs
Outputs from Neurotherapeutics
#773
of 1,307 outputs
Outputs of similar age
#28,461
of 78,648 outputs
Outputs of similar age from Neurotherapeutics
#6
of 11 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,307 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one is in the 28th percentile – i.e., 28% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,648 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.