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Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus

Overview of attention for article published in Acta Neurochirurgica, March 2018
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Title
Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus
Published in
Acta Neurochirurgica, March 2018
DOI 10.1007/s00701-018-3497-9
Pubmed ID
Authors

Afroditi-Despina Lalou, Virginia Levrini, Matthew Garnett, Eva Nabbanja, Dong-Joo Kim, Laurent Gergele, Anna Bjornson, Zofia Czosnyka, Marek Czosnyka

Abstract

The so-called Davson's equation relates baseline intracranial pressure (ICP) to resistance to cerebrospinal fluid outflow (Rout), formation of cerebrospinal fluid (If) and sagittal sinus pressure (PSS) There is a controversy over whether this fundamental equation is applicable in patients with normal pressure hydrocephalus (NPH). We investigated the relationship between Rout and ICP and also other compensatory, clinical and demographic parameters in NPH patients. We carried out a retrospective study of 229 patients with primary NPH who had undergone constant-rate infusion studies in our hospital. Data was recorded and processed using ICM+ software. Relationships between variables were sought by calculating Pearson product correlation coefficients and p values. We found a significant, albeit weak, relationship between ICP and Rout (R = 0.17, p = 0.0049), Rout and peak-to-peak amplitude of ICP (AMP) (R = 0.27, p = 3.577e-05) and Rout and age (R = 0.16, p = 0.01306). The relationship found between ICP and Rout provides indirect evidence to support disturbed Cerebrospinal fluid circulation as a key factor in disturbed CSF dynamics in NPH. Weak correlation may indicate that other factors-variable PSS and formation of CSF outflow-contribute heavily to linear model expressed by Davson's equation.

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Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 20%
Student > Bachelor 3 15%
Student > Master 2 10%
Professor 2 10%
Researcher 2 10%
Other 2 10%
Unknown 5 25%
Readers by discipline Count As %
Medicine and Dentistry 8 40%
Neuroscience 5 25%
Social Sciences 1 5%
Environmental Science 1 5%
Business, Management and Accounting 1 5%
Other 1 5%
Unknown 3 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2018.
All research outputs
#20,468,008
of 23,026,672 outputs
Outputs from Acta Neurochirurgica
#1,689
of 1,935 outputs
Outputs of similar age
#293,881
of 332,626 outputs
Outputs of similar age from Acta Neurochirurgica
#19
of 22 outputs
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