Title |
The Regulation of cGAS
|
---|---|
Published in |
Virologica Sinica, March 2018
|
DOI | 10.1007/s12250-018-0005-6 |
Pubmed ID | |
Authors |
Meiguang Xiong, Suyun Wang, Yan-Yi Wang, Yong Ran |
Abstract |
The cGAS-MITA pathway of cytosolic DNA sensing plays essential roles in immune response against pathogens that contain DNA or with DNA production in their life cycles. The cGAS-MITA pathway also detects leaked or aberrant accumulated self DNA in the cytoplasm under certain pathological conditions, such as virus induced cell death, DNA damage, mitochondria damage, gene mutations, which results in autoimmune diseases. Therefore, the cGAS-MITA pathway must be tightly controlled to ensure proper immune response against pathogens and to avoid autoimmune diseases. The regulation of cGAS-MITA pathway at MITA-level have been extensively explored and reviewed elsewhere, here we provide a summary and perspective on recent advances in understanding of the cGAS regulation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 57 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 13 | 23% |
Student > Bachelor | 8 | 14% |
Student > Master | 6 | 11% |
Student > Doctoral Student | 4 | 7% |
Student > Postgraduate | 4 | 7% |
Other | 9 | 16% |
Unknown | 13 | 23% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 21 | 37% |
Agricultural and Biological Sciences | 8 | 14% |
Immunology and Microbiology | 5 | 9% |
Engineering | 4 | 7% |
Medicine and Dentistry | 2 | 4% |
Other | 4 | 7% |
Unknown | 13 | 23% |