Title |
The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children
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Published in |
Scientific Reports, January 2018
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DOI | 10.1038/s41598-018-19718-y |
Pubmed ID | |
Authors |
Filemón Bucardo, Johan Nordgren, Yaoska Reyes, Fredman Gonzalez, Sumit Sharma, Lennart Svensson |
Abstract |
Histo-blood group antigens (HBGAs) and the Lewis and secretor antigens are associated with susceptibility to rotavirus infection in a genotype-dependent manner. Nicaraguan children were prospectively enrolled in two cohorts vaccinated with either RotaTeq RV5 (n = 68) or Rotarix RV1 (n = 168). Lewis and secretor antigens were determined by saliva phenotyping and genotyping. Seroconversion was defined as a 4-fold increase in plasma IgA antibody titer 1 month after administration of the first dose of the vaccine. Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). Furthermore, following administration of the RV1 vaccine, secretor-positive ABO blood group B children seroconverted to a significantly lesser extent (5%) compared to secretor-positive children with ABO blood groups A (26%) and O (27%) (P < 0.05). Other factors such as pre-vaccination titers, sex, breastfeeding, and calprotectin levels did not influence vaccine-take. Differences in HBGA expression appear to be a contributing factor in the discrepancy in vaccine-take and thus, in vaccine efficacy in different ethnic populations. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 59 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 15 | 25% |
Student > Master | 7 | 12% |
Researcher | 5 | 8% |
Student > Bachelor | 4 | 7% |
Student > Postgraduate | 3 | 5% |
Other | 8 | 14% |
Unknown | 17 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 8 | 14% |
Medicine and Dentistry | 7 | 12% |
Agricultural and Biological Sciences | 6 | 10% |
Immunology and Microbiology | 5 | 8% |
Social Sciences | 3 | 5% |
Other | 9 | 15% |
Unknown | 21 | 36% |