Title |
Effects of the mGluR2/3 agonist LY354740 on computerized tasks of attention and working memory in marmoset monkeys
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Published in |
Psychopharmacology, January 2005
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DOI | 10.1007/s00213-004-2126-x |
Pubmed ID | |
Authors |
Simona Spinelli, Theresa Ballard, Silvia Gatti-McArthur, Grayson J. Richards, Martin Kapps, Thomas Woltering, Jurgen Wichmann, Heinz Stadler, Joram Feldon, Christopher R. Pryce |
Abstract |
LY354740 is a recently developed metabotropic glutamatergic receptor 2 and 3 (mGluR2/3) agonist. A high density of mGluR2 has been reported in terminal fields of the perforant path in rodents and humans, suggesting its involvement in cognitive functions mediated by the temporal lobe, including memory. A small number of in vivo studies in rodents have assessed the effects of LY354740 on memory tasks, reporting the induction of impaired memory for spatial orientation in a water maze task and for delayed match and non-match to position in an operant version of these tasks. |
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