RT @AvrahamCooperMD: 7/ So what are the mechanisms of thalidomide embryopathy? There are at least 3 main theories: 🔑Ubiquitin ligase funct…
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12/ Finally, let's look at angiogenesis. Amazingly, thalidomide also has anti-angiogenic effects, which also likely disrupts limb growth by impacting blood supply development and growth factor expression. https://t.co/SIb7jTdJaw https://t.co/oalu0aIyNN
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7/ So what are the mechanisms of thalidomide embryopathy? There are at least 3 main theories: 🔑Ubiquitin ligase function 🔑Oxidative stress 🔑Anti-angiogenic effects Let's unpack each of these. https://t.co/SIb7jTeh04
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