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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)
|
|---|---|
| Published in |
Mammalian Genome, January 2004
|
| DOI | 10.1007/s00335-033-2317-5 |
| Pubmed ID | |
| Authors |
Tomoko Sagai, Hiroshi Masuya, Masaru Tamura, Kunihiko Shimizu, Yukari Yada, Shigeharu Wakana, Yoichi Gondo, Tetsuo Noda, Toshihiko Shiroishi |
| Abstract |
Polarized expression of the Sonic hedgehog ( Shh) gene in the posterior mesenchyme is essential for pattern formation in the appendages of higher vertebrates, from teleost fins to tetrapod limb buds. We report on a sequence in intron 5 of the Lmbr1 gene, which resides approximately 1 Mb from the Shh coding region in the mouse genome and is highly conserved among teleost fishes and throughout the tetrapod lineage. Positional cloning revealed that two mouse mutations, Hx and M100081, characterized by mirror-image digit duplication and ectopic anterior Shh expression, have base substitutions in this sequence. Absence of the conserved sequence in limbless reptiles and amphibians and a cis- trans test using the Hx and Shh KO alleles suggest that the sequence is a cis-acting regulator that controls the polarized expression of Shh. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 3% |
| United States | 3 | 3% |
| United Kingdom | 1 | <1% |
| South Africa | 1 | <1% |
| Spain | 1 | <1% |
| China | 1 | <1% |
| Unknown | 95 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 26% |
| Researcher | 18 | 17% |
| Professor > Associate Professor | 10 | 10% |
| Professor | 9 | 9% |
| Student > Bachelor | 9 | 9% |
| Other | 20 | 19% |
| Unknown | 12 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 57 | 54% |
| Biochemistry, Genetics and Molecular Biology | 22 | 21% |
| Unspecified | 4 | 4% |
| Computer Science | 4 | 4% |
| Immunology and Microbiology | 1 | <1% |
| Other | 3 | 3% |
| Unknown | 14 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,949,000
of 25,376,589 outputs
Outputs from Mammalian Genome
#311
of 1,107 outputs
Outputs of similar age
#33,960
of 139,951 outputs
Outputs of similar age from Mammalian Genome
#3
of 7 outputs
Altmetric has tracked 25,376,589 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,107 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 139,951 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.