Title |
Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid
|
---|---|
Published in |
Cellular and Molecular Life Sciences, January 1996
|
DOI | 10.1007/bf01922423 |
Pubmed ID | |
Authors |
M. L. Wise, K. Soderstrom, T. F. Murray, W. H. Gerwick |
Abstract |
A polyenoic fatty-acid isomerase (PFI) from a red marine alga was used to convert anandamide (5Z,8Z,11Z,14Z-eicosatetraenoyl-N-ethan olamide) to the 5Z,7E,9E,14Z-eicosatetraenoyl-N-ethanol amide isomer. This novel eicosanoid, termed conjugated triene anandamide (CTA), was assessed for its ability to bind to the cannabinoid receptor in rat brain membrane preparations. CTA is a high affinity cannabimimetic substance whose novel structure provides new insight into structure-activity relationships of cannabinoid receptor ligands. These experiments illustrate the utility of enzymes isolated from marine organisms in the development of pharmacological probes. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 7% |
Unknown | 13 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 29% |
Student > Bachelor | 2 | 14% |
Professor | 2 | 14% |
Student > Ph. D. Student | 2 | 14% |
Lecturer > Senior Lecturer | 1 | 7% |
Other | 2 | 14% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 29% |
Agricultural and Biological Sciences | 3 | 21% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 21% |
Social Sciences | 2 | 14% |
Engineering | 1 | 7% |
Other | 0 | 0% |
Unknown | 1 | 7% |