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Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid

Overview of attention for article published in Cellular and Molecular Life Sciences, January 1996
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14 Mendeley
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Title
Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid
Published in
Cellular and Molecular Life Sciences, January 1996
DOI 10.1007/bf01922423
Pubmed ID
Authors

M. L. Wise, K. Soderstrom, T. F. Murray, W. H. Gerwick

Abstract

A polyenoic fatty-acid isomerase (PFI) from a red marine alga was used to convert anandamide (5Z,8Z,11Z,14Z-eicosatetraenoyl-N-ethan olamide) to the 5Z,7E,9E,14Z-eicosatetraenoyl-N-ethanol amide isomer. This novel eicosanoid, termed conjugated triene anandamide (CTA), was assessed for its ability to bind to the cannabinoid receptor in rat brain membrane preparations. CTA is a high affinity cannabimimetic substance whose novel structure provides new insight into structure-activity relationships of cannabinoid receptor ligands. These experiments illustrate the utility of enzymes isolated from marine organisms in the development of pharmacological probes.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 14 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 7%
Unknown 13 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 4 29%
Student > Bachelor 2 14%
Professor 2 14%
Student > Ph. D. Student 2 14%
Lecturer > Senior Lecturer 1 7%
Other 2 14%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 4 29%
Agricultural and Biological Sciences 3 21%
Pharmacology, Toxicology and Pharmaceutical Science 3 21%
Social Sciences 2 14%
Engineering 1 7%
Other 0 0%
Unknown 1 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 April 2014.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from Cellular and Molecular Life Sciences
#2,146
of 5,877 outputs
Outputs of similar age
#17,062
of 80,654 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#5
of 10 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,877 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 80,654 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 5 of them.