Title |
Slit2/Robo1 signaling in glioma migration and invasion
|
---|---|
Published in |
Neuroscience Bulletin, December 2010
|
DOI | 10.1007/s12264-010-0730-9 |
Pubmed ID | |
Authors |
Yun Xu, Li Wen-Liang, Fu Li, Gu Feng, Ma Yong-Jie |
Abstract |
Slit2/Robo1 is a conserved ligand-receptor system, which greatly affects the distribution, migration, axon guidance and branching of neuron cells. Slit2 and its transmembrane receptor Robo1 have different distribution patterns in gliomas. The expression of Slit2 is at very low levels in pilocytic astrocytoma, fibrillary astrocytoma and glioblastoma, while Robo1 is highly expressed in different grades of gliomas at both mRNA and protein levels. Acquisition of insidious invasiveness by malignant glioma cells involves multiple genetic alterations in signaling pathways. Although the specific mechanisms of tumor-suppressive effect of Slit2/Robo1 have not been elucidated, it has been proved that Slit2/Robo1 signaling inhibits glioma cell migration and invasion by inactivation of Cdc42-GTP. With the research development on the molecular mechanisms of Slit2/Robo1 signaling in glioma invasion and migration, Slit2/Robo1 signaling may become a potential target for glioma prevention and treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Denmark | 1 | 3% |
Unknown | 33 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 8 | 24% |
Student > Postgraduate | 6 | 18% |
Student > Bachelor | 4 | 12% |
Researcher | 3 | 9% |
Other | 2 | 6% |
Other | 3 | 9% |
Unknown | 8 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 35% |
Biochemistry, Genetics and Molecular Biology | 5 | 15% |
Medicine and Dentistry | 5 | 15% |
Neuroscience | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 0 | 0% |
Unknown | 9 | 26% |