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Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro

Overview of attention for article published in Parasitology Research, August 2008
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Title
Castalagin from Anogeissus leiocarpus mediates the killing of Leishmania in vitro
Published in
Parasitology Research, August 2008
DOI 10.1007/s00436-008-1137-7
Pubmed ID
Authors

M. N. Shuaibu, K. Pandey, P. A. Wuyep, T. Yanagi, K. Hirayama, A. Ichinose, T. Tanaka, I. Kouno

Abstract

Stem barks of Anogeissus leiocarpus and Terminalia avicennoides widely used in Africa for treatment of some parasitic diseases were collected and made into methanolic extracts. The extracts were tested on four strains of promastigote forms of Leishmania in vitro. Solvent fractionation in aqueous, butanolic, and ethyl acetate layer indicated butanol and aqueous fractions to have a superior leishmanicidal activity. Chromatographic separation of the butanolic fraction on Sephadex LH-20 followed by nuclear magnetic resonance and correlation high-performance liquid chromatography revealed the presence of known hydrolyzable tannins and some related compounds-with castalagin as the major compound. The observed activity ranged from 62.5 to > or =150, 112.5 to > or =500, and 55 to >150 microg/ml for the crude methanolic extract, different solvent fractions, and the isolated compounds, respectively, on the four different Leishmania strains.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 54 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 25%
Researcher 6 11%
Student > Master 6 11%
Student > Doctoral Student 5 9%
Student > Bachelor 3 5%
Other 8 15%
Unknown 13 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 20%
Pharmacology, Toxicology and Pharmaceutical Science 9 16%
Chemistry 5 9%
Medicine and Dentistry 3 5%
Biochemistry, Genetics and Molecular Biology 3 5%
Other 6 11%
Unknown 18 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 February 2021.
All research outputs
#8,882,501
of 26,017,215 outputs
Outputs from Parasitology Research
#773
of 4,245 outputs
Outputs of similar age
#37,462
of 103,389 outputs
Outputs of similar age from Parasitology Research
#9
of 26 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,245 research outputs from this source. They receive a mean Attention Score of 3.0. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 103,389 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 3rd percentile – i.e., 3% of its contemporaries scored the same or lower than it.