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Mendeley readers
Attention Score in Context
| Title |
Relationship between the hypothalamic–pituitary–adrenal-axis and fatty acid metabolism in recurrent depression
|
|---|---|
| Published in |
Psychoneuroendocrinology, March 2013
|
| DOI | 10.1016/j.psyneuen.2013.01.013 |
| Pubmed ID | |
| Authors |
Roel J.T. Mocking, Henricus G. Ruhé, Johanna Assies, Anja Lok, Maarten W.J. Koeter, Ieke Visser, Claudi L.H. Bockting, Aart H. Schene |
| Abstract |
Alterations in hypothalamic-pituitary-adrenal (HPA)-axis activity and fatty acid (FA)-metabolism have been observed in (recurrent) major depressive disorder (MDD). Through the pathophysiological roles of FAs in the brain and cardiovascular system, a hypothesized relationship between HPA-axis activity and FA-metabolism could form a possible missing link accounting for the association of HPA-axis hyperactivity with recurrence and cardiovascular disease in MDD. In 137 recurrent MDD-patients and 73 age- and sex-matched controls, we therefore investigated associations between salivary cortisol (morning and evening) and the following indicators of FA-metabolism measured in the red blood cell membrane: (I) three main FAs [eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid (AA)], and (II) structural FA indices (unsaturation, chain length, peroxidation) calculated from concentrations of 29 FAs to delineate overall FA-characteristics. In addition, we compared these associations in patients with those in controls. In patients, evening cortisol concentrations were significantly negatively associated with DHA (B=-1.358; SE=0.499; t=-2.72; p=.006), the unsaturation index (B=-0.021; SE=0.009; t=-2.42; p=.018), chain length index (B=-0.060; SE=0.025; t=-2.41; p=.019), and peroxidation index (B=-0.029; SE=0.012; t=-2.48; p=.015). The relations between cortisol and the latter three variables were significantly negative in patients relative to controls. Significance remained after correction for confounders. Our results suggest a relationship between HPA-axis activity and FA-metabolism in recurrent MDD. Future randomized experimental intervention studies using clinical outcome measures could help to further elucidate the suggested effects of hypercortisolemia in the brain and cardiovascular system in recurrent MDD. |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| United States | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 20 | 16% |
| Student > Ph. D. Student | 18 | 15% |
| Student > Master | 18 | 15% |
| Researcher | 15 | 12% |
| Student > Postgraduate | 7 | 6% |
| Other | 18 | 15% |
| Unknown | 26 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 19% |
| Psychology | 14 | 11% |
| Nursing and Health Professions | 14 | 11% |
| Agricultural and Biological Sciences | 13 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Other | 16 | 13% |
| Unknown | 33 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 February 2015.
All research outputs
#22,759,802
of 25,374,917 outputs
Outputs from Psychoneuroendocrinology
#3,465
of 3,904 outputs
Outputs of similar age
#183,438
of 207,695 outputs
Outputs of similar age from Psychoneuroendocrinology
#34
of 46 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,904 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 207,695 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.