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Mendeley readers
Attention Score in Context
| Title |
High-fidelity patch-clamp recordings from neurons cultured on a polymer microchip
|
|---|---|
| Published in |
Biomedical Microdevices, August 2010
|
| DOI | 10.1007/s10544-010-9452-z |
| Pubmed ID | |
| Authors |
Dolores Martinez, Christophe Py, Mike W. Denhoff, Marzia Martina, Robert Monette, Tanya Comas, Collin Luk, Naweed Syed, Geoff Mealing |
| Abstract |
We present a polymer microchip capable of monitoring neuronal activity with a fidelity never before obtained on a planar patch-clamp device. Cardio-respiratory neurons Left Pedal Dorsal 1 (LPeD1) from mollusc Lymnaea were cultured on the microchip's polyimide surface for 2 to 4 hours. Cultured neurons formed high resistance seals (gigaseals) between the cell membrane and the surface surrounding apertures etched in the polyimide. Gigaseal formation was observed without applying external force, such as suction, on neurons. The formation of gigaseals, as well as the low access resistance and shunt capacitance values of the polymer microchip resulted in high-fidelity recordings. On-chip culture of neurons permitted, for the first time on a polymeric patch-clamp device, the recording of high fidelity physiological action potentials. Microfabrication of the hybrid poly(dimethylsiloxane)-polyimide (PDMS-PI) microchip is discussed, including a two-layer PDMS processing technique resulting in minimized shrinking variations. |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Denmark | 2 | 3% |
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 68 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 24 | 32% |
| Student > Ph. D. Student | 16 | 22% |
| Student > Master | 11 | 15% |
| Professor | 4 | 5% |
| Student > Bachelor | 3 | 4% |
| Other | 10 | 14% |
| Unknown | 6 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 17 | 23% |
| Physics and Astronomy | 12 | 16% |
| Agricultural and Biological Sciences | 11 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Medicine and Dentistry | 4 | 5% |
| Other | 13 | 18% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2024.
All research outputs
#5,411,714
of 25,323,244 outputs
Outputs from Biomedical Microdevices
#105
of 799 outputs
Outputs of similar age
#21,798
of 101,632 outputs
Outputs of similar age from Biomedical Microdevices
#2
of 15 outputs
Altmetric has tracked 25,323,244 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 101,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.