Title |
Differential effects of self-reported lifetime marijuana use on interleukin-1 alpha and tumor necrosis factor in African American adults
|
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Published in |
Journal of Behavioral Medicine, March 2015
|
DOI | 10.1007/s10865-015-9625-6 |
Pubmed ID | |
Authors |
Larry Keen, Arlener D. Turner |
Abstract |
It is unknown how lifetime marijuana use affects different proinflammatory cytokines. The purpose of the current study is to explore potential differential effects of lifetime marijuana use on interleukin-1 alpha (IL-1α) and tumor necrosis factor (TNF) in a community based sample. Participants included 168 African American adults (51 % female, median age = 47 years). Upon study entry, blood was drawn and the participants completed questions regarding illicit drug use history whose answers were used to create three groups: lifetime non-drug users (n = 77), lifetime marijuana only users (n = 46) and lifetime marijuana and other drug users (n = 45). In the presence of demographic and physiological covariates, non-drug users were approximately two times more likely (AOR 2.73, CI 1.18, 6.31; p = .03) to have higher TNF levels than marijuana only users. Drug use was not associated with IL-1α. The influence of marijuana may be selective in nature, potentially localizing around innate immunity and the induction of cellular death. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 46 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 14 | 30% |
Student > Bachelor | 10 | 21% |
Researcher | 6 | 13% |
Other | 3 | 6% |
Student > Postgraduate | 2 | 4% |
Other | 5 | 11% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 17 | 36% |
Medicine and Dentistry | 5 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
Immunology and Microbiology | 2 | 4% |
Nursing and Health Professions | 2 | 4% |
Other | 10 | 21% |
Unknown | 8 | 17% |