You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes
|
|---|---|
| Published in |
Diabetologia, April 2018
|
| DOI | 10.1007/s00125-018-4602-6 |
| Pubmed ID | |
| Authors |
Cynthia M. F. Monaco, Meghan C. Hughes, Sofhia V. Ramos, Nina E. Varah, Christian Lamberz, Fasih A. Rahman, Chris McGlory, Mark A. Tarnopolsky, Matthew P. Krause, Robert Laham, Thomas J. Hawke, Christopher G. R. Perry |
| Abstract |
A comprehensive assessment of skeletal muscle ultrastructure and mitochondrial bioenergetics has not been undertaken in individuals with type 1 diabetes. This study aimed to systematically assess skeletal muscle mitochondrial phenotype in young adults with type 1 diabetes. Physically active, young adults (men and women) with type 1 diabetes (HbA1c 63.0 ± 16.0 mmol/mol [7.9% ± 1.5%]) and without type 1 diabetes (control), matched for sex, age, BMI and level of physical activity, were recruited (n = 12/group) to undergo vastus lateralis muscle microbiopsies. Mitochondrial respiration (high-resolution respirometry), site-specific mitochondrial H2O2 emission and Ca2+ retention capacity (CRC) (spectrofluorometry) were assessed using permeabilised myofibre bundles. Electron microscopy and tomography were used to quantify mitochondrial content and investigate muscle ultrastructure. Skeletal muscle microvasculature was assessed by immunofluorescence. Mitochondrial oxidative capacity was significantly lower in participants with type 1 diabetes vs the control group, specifically at Complex II of the electron transport chain, without differences in mitochondrial content between groups. Muscles of those with type 1 diabetes also exhibited increased mitochondrial H2O2 emission at Complex III and decreased CRC relative to control individuals. Electron tomography revealed an increase in the size and number of autophagic remnants in the muscles of participants with type 1 diabetes. Despite this, levels of the autophagic regulatory protein, phosphorylated AMP-activated protein kinase (p-AMPKαThr172), and its downstream targets, phosphorylated Unc-51 like autophagy activating kinase 1 (p-ULK1Ser555) and p62, was similar between groups. In addition, no differences in muscle capillary density or platelet aggregation were observed between the groups. Alterations in mitochondrial ultrastructure and bioenergetics are evident within the skeletal muscle of active young adults with type 1 diabetes. It is yet to be elucidated whether more rigorous exercise may help to prevent skeletal muscle metabolic deficiencies in both active and inactive individuals with type 1 diabetes. |
X Demographics
The data shown below were collected from the profiles of 44 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 9 | 20% |
| United States | 6 | 14% |
| United Kingdom | 5 | 11% |
| India | 2 | 5% |
| Malaysia | 1 | 2% |
| Argentina | 1 | 2% |
| Denmark | 1 | 2% |
| Australia | 1 | 2% |
| France | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 15 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 50% |
| Scientists | 17 | 39% |
| Practitioners (doctors, other healthcare professionals) | 4 | 9% |
| Unknown | 1 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 18 | 20% |
| Student > Ph. D. Student | 11 | 12% |
| Student > Bachelor | 11 | 12% |
| Researcher | 7 | 8% |
| Student > Postgraduate | 4 | 4% |
| Other | 9 | 10% |
| Unknown | 31 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Nursing and Health Professions | 11 | 12% |
| Medicine and Dentistry | 9 | 10% |
| Agricultural and Biological Sciences | 9 | 10% |
| Sports and Recreations | 6 | 7% |
| Other | 9 | 10% |
| Unknown | 35 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 588. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2022.
All research outputs
#34,171
of 23,577,654 outputs
Outputs from Diabetologia
#31
of 5,140 outputs
Outputs of similar age
#861
of 328,505 outputs
Outputs of similar age from Diabetologia
#1
of 60 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,140 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,505 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.