A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2
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Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when…
Cells carrying a monoallelic germline BRCA2 mutation can bypass Knudson’s “two-hit” requirement to initiate tumorigenesis when…
Seven words someone taking a genetic test doesn’t want to hear: “You have a variant of uncertain significance.” A VUS. Instead…
Caption: “Homologous Hope” sculpture at University of Pennsylvania depicting the part of the BRCA2 gene involved in DNA repair.Cr…
Doctors have long recognized that women with mutations in two particular genes – BRCA1 and BRCA2 – have a higher risk of breast…