Title |
The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development
|
---|---|
Published in |
Cell Host & Microbe (Science Direct), April 2015
|
DOI | 10.1016/j.chom.2015.03.008 |
Pubmed ID | |
Authors |
Shu Mei Teo, Danny Mok, Kym Pham, Merci Kusel, Michael Serralha, Niamh Troy, Barbara J. Holt, Belinda J. Hales, Michael L. Walker, Elysia Hollams, Yury A. Bochkov, Kristine Grindle, Sebastian L. Johnston, James E. Gern, Peter D. Sly, Patrick G. Holt, Kathryn E. Holt, Michael Inouye |
Abstract |
The nasopharynx (NP) is a reservoir for microbes associated with acute respiratory infections (ARIs). Lung inflammation resulting from ARIs during infancy is linked to asthma development. We examined the NP microbiome during the critical first year of life in a prospective cohort of 234 children, capturing both the viral and bacterial communities and documenting all incidents of ARIs. Most infants were initially colonized with Staphylococcus or Corynebacterium before stable colonization with Alloiococcus or Moraxella. Transient incursions of Streptococcus, Moraxella, or Haemophilus marked virus-associated ARIs. Our data identify the NP microbiome as a determinant for infection spread to the lower airways, severity of accompanying inflammatory symptoms, and risk for future asthma development. Early asymptomatic colonization with Streptococcus was a strong asthma predictor, and antibiotic usage disrupted asymptomatic colonization patterns. In the absence of effective anti-viral therapies, targeting pathogenic bacteria within the NP microbiome could represent a prophylactic approach to asthma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 7 | 15% |
Australia | 4 | 9% |
United Kingdom | 3 | 6% |
France | 2 | 4% |
Spain | 2 | 4% |
Canada | 1 | 2% |
Malawi | 1 | 2% |
Ecuador | 1 | 2% |
China | 1 | 2% |
Other | 3 | 6% |
Unknown | 22 | 47% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 27 | 57% |
Scientists | 17 | 36% |
Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 8 | 1% |
Korea, Republic of | 3 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Japan | 1 | <1% |
Canada | 1 | <1% |
Unknown | 649 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 122 | 18% |
Researcher | 120 | 18% |
Student > Bachelor | 78 | 12% |
Student > Master | 54 | 8% |
Other | 36 | 5% |
Other | 103 | 16% |
Unknown | 151 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 121 | 18% |
Agricultural and Biological Sciences | 112 | 17% |
Immunology and Microbiology | 89 | 13% |
Biochemistry, Genetics and Molecular Biology | 78 | 12% |
Nursing and Health Professions | 12 | 2% |
Other | 61 | 9% |
Unknown | 191 | 29% |