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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A proinflammatory CD4+ T cell phenotype in gestational diabetes mellitus
|
|---|---|
| Published in |
Diabetologia, April 2018
|
| DOI | 10.1007/s00125-018-4615-1 |
| Pubmed ID | |
| Authors |
Angela Sheu, Yixian Chan, Angela Ferguson, Mohammad B. Bakhtyari, Wendy Hawke, Chris White, Yuk Fun Chan, Patrick J. Bertolino, Heng G. Woon, Umaimainthan Palendira, Frederic Sierro, Sue Mei Lau |
| Abstract |
Numerous adaptations of the maternal immune system are necessary during pregnancy to maintain immunological tolerance to the semi-allogeneic fetus. Several complications of pregnancy have been associated with dysregulation of these adaptive mechanisms. While gestational diabetes mellitus (GDM) has been associated with upregulation of circulating inflammatory factors linked to innate immunity, polarisation of the adaptive immune system has not been extensively characterised in this condition. We aimed to characterise pro- and anti-inflammatory CD4+ (T helper [Th]) T cell subsets in women with GDM vs women without GDM (of similar BMI), during and after pregnancy, and examine the relationship between CD4+ subsets and severity of GDM. This is a prospective longitudinal case-control study of 55 women with GDM (cases) and 65 women without GDM (controls) at a tertiary maternity hospital. Quantification of proinflammatory (Th17, Th17.1, Th1) and anti-inflammatory (regulatory T cell [Treg]) CD4+ T cell subsets was performed on peripheral blood at 37 weeks gestation and 7 weeks postpartum, and correlated with clinical characteristics and measures of blood glucose. Women with GDM had a significantly greater percentage of Th17 (median 2.49% [interquartile range 1.62-4.60] vs 1.85% [1.13-2.98], p = 0.012) and Th17.1 (3.06% [1.30-4.33] vs 1.55% [0.65-3.13], p = 0.006) cells compared with the control group of women without GDM. Women with GDM also had higher proinflammatory cell ratios (Th17:Treg, Th17.1:Treg and Th1:Treg) in pregnancy compared with the control group of women without GDM. In the control group, there was a statistically significant independent association between 1 h glucose levels in the GTT and Th17 cell percentages, and also between 2 h glucose levels and percentage of Th17 cells. The percentage of Th17 cells and the Th17:Treg ratio declined significantly after delivery in women with GDM, whereas this was not the case with the control group of women. Nevertheless, a milder inflammatory phenotype persisted after delivery (higher Th17:Treg ratio) in women with GDM vs women without. Dysregulation of adaptive immunity supports a novel paradigm of GDM that extends beyond hyperglycaemia and altered innate immunity. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 20% |
| Spain | 2 | 20% |
| Chile | 1 | 10% |
| Unknown | 5 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 50% |
| Practitioners (doctors, other healthcare professionals) | 3 | 30% |
| Scientists | 1 | 10% |
| Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 17% |
| Student > Bachelor | 5 | 12% |
| Student > Master | 4 | 10% |
| Researcher | 3 | 7% |
| Student > Doctoral Student | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 14 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 27% |
| Biochemistry, Genetics and Molecular Biology | 7 | 17% |
| Immunology and Microbiology | 6 | 15% |
| Agricultural and Biological Sciences | 1 | 2% |
| Unspecified | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 13 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2018.
All research outputs
#6,179,141
of 23,045,021 outputs
Outputs from Diabetologia
#2,538
of 5,092 outputs
Outputs of similar age
#107,664
of 326,487 outputs
Outputs of similar age from Diabetologia
#46
of 60 outputs
Altmetric has tracked 23,045,021 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 5,092 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 22.7. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,487 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.