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Longitudinal FDG microPET imaging of neuropathic pain: does cerebellar activity correlate with neuropathic pain development in a rat model?

Overview of attention for article published in Acta Neurochirurgica, April 2015
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Title
Longitudinal FDG microPET imaging of neuropathic pain: does cerebellar activity correlate with neuropathic pain development in a rat model?
Published in
Acta Neurochirurgica, April 2015
DOI 10.1007/s00701-015-2415-7
Pubmed ID
Authors

Jinhyung Kim, Jaewoo Shin, Jin-Hwan Oh, Hyun Ho Jung, Young-Bo Kim, Zang-Hee Cho, Jin Woo Chang

Abstract

We used [F-18] FDG microPET imaging as part of a longitudinal study to investigate changes in the brain. Glucose metabolism during the development of neuropathic pain after tibial and sural nerve transection (TST) model rats. MicroPET images were obtained 1 week before operation and then weekly for 8 weeks post-operation. The behavioral test was performed immediately after the every FDG administration. After TST modeling, neuropathic pain rats showed increased mechanical sensitivity of the injured hind paw. The withdrawal response to mechanical pain stimulation by von Frey filaments was observed within the first week (3.8 ± 0.73), and it rapidly increased in the third week (7.13 ± 0.82). This response reached a peak in the fourth week after surgery (9.0 ± 0.53), which persisted until the eighth week. In microPET scan imaging, cerebellum, which initially started from the ansiform lobule, was activated gradually to all part from the third week in all image acquisitions through the eighth week. The longitudinal microPET scan study of brains from neuropathic pain rat models showed sequential cerebellar activity that was in accordance with results from behavioral test responses, thus supporting a role for the cerebellum in the development of neuropathic pain.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 17 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 29%
Researcher 3 18%
Student > Bachelor 3 18%
Other 1 6%
Student > Doctoral Student 1 6%
Other 2 12%
Unknown 2 12%
Readers by discipline Count As %
Medicine and Dentistry 6 35%
Agricultural and Biological Sciences 2 12%
Neuroscience 2 12%
Psychology 1 6%
Pharmacology, Toxicology and Pharmaceutical Science 1 6%
Other 2 12%
Unknown 3 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2015.
All research outputs
#20,269,439
of 22,800,560 outputs
Outputs from Acta Neurochirurgica
#1,674
of 1,911 outputs
Outputs of similar age
#222,913
of 264,516 outputs
Outputs of similar age from Acta Neurochirurgica
#10
of 13 outputs
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So far Altmetric has tracked 1,911 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.