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Issues in Clinical Epileptology: A View from the Bench

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Cover of 'Issues in Clinical Epileptology: A View from the Bench'

Table of Contents

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    Book Overview
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    Chapter 1 How Can We Identify Ictal and Interictal Abnormal Activity?
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    Chapter 2 What Is the Clinical Relevance of In Vitro Epileptiform Activity?
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    Chapter 3 What Is the Importance of Abnormal “Background” Activity in Seizure Generation?
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    Chapter 4 What Is a Seizure Focus?
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    Chapter 5 What Is a Seizure Network? Long-Range Network Consequences of Focal Seizures
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    Chapter 6 What Is a Seizure Network? Very Fast Oscillations at the Interface Between Normal and Epileptic Brain
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    Chapter 7 Is There Such a Thing as “Generalized” Epilepsy?
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    Chapter 8 Are There Really “Epileptogenic” Mechanisms or Only Corruptions of “Normal” Plasticity?
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    Chapter 9 When and How Do Seizures Kill Neurons, and Is Cell Death Relevant to Epileptogenesis?
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    Chapter 10 How Is Homeostatic Plasticity Important in Epilepsy?
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    Chapter 11 Is Plasticity of GABAergic Mechanisms Relevant to Epileptogenesis?
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    Chapter 12 Do Structural Changes in GABA Neurons Give Rise to the Epileptic State?
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    Chapter 13 Does Mossy Fiber Sprouting Give Rise to the Epileptic State?
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    Chapter 14 Does Brain Inflammation Mediate Pathological Outcomes in Epilepsy?
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    Chapter 15 Are Changes in Synaptic Function That Underlie Hyperexcitability Responsible for Seizure Activity?
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    Chapter 16 Does Epilepsy Cause a Reversion to Immature Function?
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    Chapter 17 Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?
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    Chapter 18 How Do We Make Models That Are Useful in Understanding Partial Epilepsies?
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    Chapter 19 Aligning Animal Models with Clinical Epilepsy: Where to Begin?
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    Chapter 20 What Non-neuronal Mechanisms Should Be Studied to Understand Epileptic Seizures?
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    Chapter 21 What Epilepsy Comorbidities Are Important to Model in the Laboratory? Clinical Perspectives
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    Chapter 22 Epilepsy Comorbidities: How Can Animal Models Help?
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    Chapter 23 What New Modeling Approaches Will Help Us Identify Promising Drug Treatments?
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    Chapter 24 What are the arguments for and against rational therapy for epilepsy?
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    Chapter 25 How Can Advances in Epilepsy Genetics Lead to Better Treatments and Cures?
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    Chapter 26 How Might Novel Technologies Such as Optogenetics Lead to Better Treatments in Epilepsy?
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