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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death
|
|---|---|
| Published in |
Cell, July 2015
|
| DOI | 10.1016/j.cell.2015.06.049 |
| Pubmed ID | |
| Authors |
Malgorzata Borowiak, Wallis Nahaboo, Martin Reynders, Katharina Nekolla, Pierre Jalinot, Jens Hasserodt, Markus Rehberg, Marie Delattre, Stefan Zahler, Angelika Vollmar, Dirk Trauner, Oliver Thorn-Seshold |
| Abstract |
Small molecules that interfere with microtubule dynamics, such as Taxol and the Vinca alkaloids, are widely used in cell biology research and as clinical anticancer drugs. However, their activity cannot be restricted to specific target cells, which also causes severe side effects in chemotherapy. Here, we introduce the photostatins, inhibitors that can be switched on and off in vivo by visible light, to optically control microtubule dynamics. Photostatins modulate microtubule dynamics with a subsecond response time and control mitosis in living organisms with single-cell spatial precision. In longer-term applications in cell culture, photostatins are up to 250 times more cytotoxic when switched on with blue light than when kept in the dark. Therefore, photostatins are both valuable tools for cell biology, and are promising as a new class of precision chemotherapeutics whose toxicity may be spatiotemporally constrained using light. |
X Demographics
The data shown below were collected from the profiles of 79 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 24% |
| United Kingdom | 10 | 13% |
| Germany | 4 | 5% |
| Japan | 4 | 5% |
| Curaçao | 1 | 1% |
| Finland | 1 | 1% |
| Canada | 1 | 1% |
| Norway | 1 | 1% |
| France | 1 | 1% |
| Other | 4 | 5% |
| Unknown | 33 | 42% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 51 | 65% |
| Scientists | 23 | 29% |
| Science communicators (journalists, bloggers, editors) | 3 | 4% |
| Practitioners (doctors, other healthcare professionals) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 614 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 1% |
| Switzerland | 3 | <1% |
| Germany | 2 | <1% |
| Poland | 2 | <1% |
| Japan | 2 | <1% |
| Taiwan | 1 | <1% |
| Denmark | 1 | <1% |
| Spain | 1 | <1% |
| Austria | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 592 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 140 | 23% |
| Researcher | 119 | 19% |
| Student > Bachelor | 59 | 10% |
| Student > Master | 46 | 7% |
| Student > Doctoral Student | 39 | 6% |
| Other | 100 | 16% |
| Unknown | 111 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 154 | 25% |
| Chemistry | 139 | 23% |
| Biochemistry, Genetics and Molecular Biology | 96 | 16% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 3% |
| Medicine and Dentistry | 17 | 3% |
| Other | 62 | 10% |
| Unknown | 128 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 281. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2023.
All research outputs
#128,009
of 25,837,817 outputs
Outputs from Cell
#722
of 17,278 outputs
Outputs of similar age
#1,202
of 277,662 outputs
Outputs of similar age from Cell
#4
of 171 outputs
Altmetric has tracked 25,837,817 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,278 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.7. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,662 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 171 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.