Title |
Transcriptional Regulation of the p16 Tumor Suppressor Gene.
|
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Published in |
Anticancer Research: International Journal of Cancer Research and Treatment, August 2015
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Pubmed ID | |
Authors |
Yojiro Kotake, Madoka Naemura, Chihiro Murasaki, Yasutoshi Inoue, Haruna Okamoto |
Abstract |
The p16 tumor suppressor gene encodes a specific inhibitor of cyclin-dependent kinase (CDK) 4 and 6 and is found altered in a wide range of human cancers. p16 plays a pivotal role in tumor suppressor networks through inducing cellular senescence that acts as a barrier to cellular transformation by oncogenic signals. p16 protein is relatively stable and its expression is primary regulated by transcriptional control. Polycomb group (PcG) proteins associate with the p16 locus in a long non-coding RNA, ANRIL-dependent manner, leading to repression of p16 transcription. YB1, a transcription factor, also represses the p16 transcription through direct association with its promoter region. Conversely, the transcription factors Ets1/2 and histone H3K4 methyltransferase MLL1 directly bind to the p16 locus and mediate p16 induction during replicative and premature senescence. In the present review, we discuss the molecular mechanisms by which these factors regulate p16 transcription. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Canada | 1 | <1% |
Unknown | 101 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 31 | 30% |
Researcher | 16 | 16% |
Student > Master | 15 | 15% |
Student > Bachelor | 10 | 10% |
Student > Doctoral Student | 5 | 5% |
Other | 13 | 13% |
Unknown | 13 | 13% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 39 | 38% |
Agricultural and Biological Sciences | 24 | 23% |
Medicine and Dentistry | 14 | 14% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
Neuroscience | 3 | 3% |
Other | 6 | 6% |
Unknown | 13 | 13% |