Title |
MicroRNA-153 Regulates the Acquisition of Gliogenic Competence by Neural Stem Cells
|
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Published in |
Stem Cell Reports, July 2015
|
DOI | 10.1016/j.stemcr.2015.06.006 |
Pubmed ID | |
Authors |
Jun Tsuyama, Jens Bunt, Linda J. Richards, Hiroko Iwanari, Yasuhiro Mochizuki, Takao Hamakubo, Takuya Shimazaki, Hideyuki Okano |
Abstract |
Mammalian neural stem/progenitor cells (NSPCs) sequentially generate neurons and glia during CNS development. Here we identified miRNA-153 (miR-153) as a modulator of the temporal regulation of NSPC differentiation. Overexpression (OE) of miR-153 delayed the onset of astrogliogenesis and maintained NSPCs in an undifferentiated state in vitro and in the developing cortex. The transcription factors nuclear factor I (NFI) A and B, essential regulators of the initiation of gliogenesis, were found to be targets of miR-153. Inhibition of miR-153 in early neurogenic NSPCs induced precocious gliogenesis, whereas NFIA/B overexpression rescued the anti-gliogenic phenotypes induced by miR-153 OE. Our results indicate that miR-mediated fine control of NFIA/B expression is important in the molecular networks that regulate the acquisition of gliogenic competence by NSPCs in the developing CNS. |
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Mendeley readers
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